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ObjectiveTo explore the status of breastfeeding and complementary feeding of infants and toddlers at 6 and 12 months of age， and to analyze the related influencing factors to inform interventions for breastfeeding and complementary feeding problems in infants and toddlers. MethodsA total of 910 children selected from Pudong New Area of the Shanghai maternal-child pairs cohort， who completed follow-up at 6 and 12 months of age， were included in the study. A feeding status questionnaire completed by the parents was used to understand the breastfeeding and complementary feeding status of children at 6 and 12 months of age， and correlation analysis was conducted between the breastfeeding and complementary feeding status and the influencing factors. ResultsThe breastfeeding rate of infants at 6 months was 76.2% （693/909）， with a higher rate among girls than boys， and the rate of continuous breastfeeding at 12 months was 35.5% （322/906）. The minimum dietary diversity （MDD） pass rate at 6 months was 16.1% （146/906）， higher in boys than in girls （χ2 =5.384， P<0.05）. The MDD pass rate at 12 months was 61.6% （554/899）. The likelihood of MDD failure in 6-month-old boys was 1.499 times higher than that in girls. Feeding of oils and their products， beverages （fruit juices）， and snacks （chocolates， candies， cakes， cookies， etc.） were risk factors for MDD failure in 6‒ and 12‒month-old children. Compared with no intake of oils and their products， beverage and snacks， the OR （95% CI） for MDD failure in 6-month-old infants fed with oils and their products， beverage and snacks were 5.866 （2.496‒13788）， 4.542 （2.943‒7.010）， and 2.599 （1.243‒5.261）， respectively. Compared with the non-fed group， the OR （95% CI） of MDD failure in infants aged 12 months fed with oils and their products， snacks， and sweet drinks were 2.335 （1.736‒3.140）， 1.549 （1.107‒2.168）， and 1.485 （1.116‒1.976）， respectively （P<0.05）. ConclusionsThe rate of continuous breastfeeding in children at 12 months in the Pudong New Area of Shanghai is low， and the dietary structure of children is unreasonable. Improvements are needed in the introduction of complementary foods. Unhealthy foods such as oils and their products， beverages， and snacks are all high-risk factors for MDD failure in children at 6 and 12 months.
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Objective:To explore the association between chest high resolution CT (HRCT) scoring and prognostic factors of interstitial lung disease (ILD) in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM).Methods:The patients with DM admitted to Kailuan General Hospital between January 2017 and December 2019 were included into the study including 13 patients with positiveanti-MDA5 antibody (7 survivors, 6 deaths) and 18 patients with anti-synthase (ARS)-antibody positive. All patients underwent chest HRCT prior to treatment. The consolidation, ground-glass opacity (GGO) and fibrosis were scored to assess HRCT findings. The clinical manifestations were compared between the two groups. Cox regression analysis adjusted for age and sex was used to determine the prognostic factors for anti-MDA5 antibody-related ILD.Results:Compared with ARS patients, glutamyl transferase (GGT) and ferritin levels were significantly higher in MDA5-ILD patients [70.0(37.0, 122.5) vs 21.0(16.5, 33.5), Z=-3.37, P=0.001; 977.0(502.5, 1 366.0) vs 307.1(72.3, 546.9) , Z=-3.44, P=0.001]. The cumulative survival rate was significantly lower in patients with positive anti-MDA5 antibody than in those with positive anti-ARS antibody (100% vs 70%, P=0.001). The DM complicated with acute/subacute interstitial pneumonia (A/SIP) were found to significantly relate to death. There were no significant differences in chest HRCT scoringbetween the survivors and the deceased patients [ HR=1.08, 95% CI(0.95, 1.23), P=0.229; HR=0.97, 95% CI(0.72, 1.30), P=0.814]. Conclusion:Anti-MDA5 antibody is an important index for early diagnosis of DM complicated with acute/subacute interstitial pneumonia (A/SIP). The chest HRCT scoreis is not associated with the prognosis of anti-MDA5 antibody-related ILD patients.
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Objective To investigate the correlation between cumulative serum uric acid (cumUA) and brachial-ankle pulse wave velocity (baPWV).Methods Among the workers who participated in the four health check-up of Kailuan Group from 2010 to 2017,subjects who completed one PWV test were selected.The subjects who met the selection criteria were 20 688,subjects who lacked the first three uric acid tests and sex data were excluded.The subjects who had ischemic stroke (excluding lacunar infarction),transient ischemic attack and myocardial infarction were excluded.Decreased subjects were excluded and the extreme value were also excluded,20 295 subjects eventually meet the inclusion criteria and were included for statistical analysis.Stepwise linear regression,multivariate logistic regression and natural spline function were used to analyze the relationship between cumUA and baPWV and the influence of cumUA on baPWV.Results Among 20 295 subjects,the incidence of baPWV ≥ 14 m/s (criteria for judging atherosclerosis) increased with the increase of cumUA.There was significant difference in the incidence of baPWV ≥ 14 m/s (53.07％,54.35％,56.42％,58.41％,61.91％) among different cumUA partition groups (β=0.11,P＜0.01).In stepwise linear regression analysis,after adjusting for other confounding factors,it was found that cumUA was positively correlated with baPWV.In multivariate logistic regression analysis,after adjusting for other confounding factors,the results showed that baPWV ≥aPWVm were all risk factors for the third,fourth and fifth subgroups of cumUA compared with the first subgroup,and the OR05％CI) was 1.35(1.13,1.62) (P=0.01),1.60(1.29,1.97) (P＜0.01) and 2.14(1.64,2.80) (P＜0.01),respectively.Natural spline analysis exhibited a similar J curve relationship between cumUA and increased baPWV.Conclusion CumUA is a risk factor for increased baPWV.
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Objective To investigate the relationship between serum uric acid ( UA) level and brachial?ankle pulse wave velocity ( baPWV) in patients with systemic lupus erythematosus ( SLE) and lupus nephritis (LN)??Methods A total of 110 hospitalized,out?patient and healthy examinees from January 2017 to September 2017 were selected from Kailuan General Hospital??They were divided into three groups:(1)Fifty?five healthy controls were examined at the same time,and those who had no history of hypertension, myocardial infarction and stroke were excluded by physical examination??(2)Thirty?four SLE patients without LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology ( ACR) in 1997,excluding those with lupus nephritis??( 3) 21 SLE patients with LN were diagnosed according to the SLE classification standard revised by the American Society of Rheumatology (ACR) in 1997??Pearson correlation coefficient and multivariate linear regression model were used to analyze the related factors affecting baPWV??Results The level of baPWV and the proportion of baPWV (≥1400 cm／s) in SLE without LN group and SLE with LN group were higher than those in healthy control group (all P＜0??05)??In SLE without LN group, baPWV was positively correlated with age, systolic blood pressure (SBP) and total cholesterol ( CHOL) ( r＝ 0??623,0??528,0??402, P＜0??01 or P＜0??05), and negatively correlated with blood uric acid(UA) ( r＝－0??371,P＜0??05),but the correlation was not significant??The correlation between UA and baPWV disappeared after after correction of age,SBP,diastolic blood pressure (DBP) by partial correlation analysis??In SLE with LN group,baPWV was positively correlated with SBP, DBP and serum creatinine ( Cr) ( r＝0??815, 0??725, 0??464, P＜0??01 or P＜0??05)??Multivariate stepwise regression analysis showed that SBP was independently correlated with baPWV in SLE group ( t＝2??54,P＝0??026); UA in SLE group without LN was independently negatively correlated with baPWV(t＝－2??96,P＝0??042); UA(t＝4??24,P＝0??013) and SBP(t＝7??70,P＝0??002) were independently positively correlated with baPWV in SLE group with LN??Logistic regression analysis showed that SLE was a risk factor for baPWV (≥1 400 cm／s),and the OR (95% CI) was 4??31 ( 1??56－11??88),P＝0??005,and there was statistical significance after adjusting for age,SBP,DBP,body mass index ( BMI)??However,UA was not a risk factor for baPWV (≥1 400 cm／s) (P values were 0??163 and 0??519,respectively)??Conclusion The degree of arteriosclerosis in SLE patients is higher than that in normal subjects,and the level of UA in SLE patients may be related to baPWV??
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OBJECTIVE@#To study the correlation between the stromal cell-derived factor (SDF-1) and the receptor fusin (CXCR4) in carcinoma of larynx, and investigate some mechanisms of SDF-1/CXCR4 during the development, invasion and lymph node metastasis of laryngocarcinoma.@*METHOD@#Detecting the expression of SDF-1 and CXCR4 by immunohistochemical method (SP) in laryngocarcinoma, paraneoplastic tissues, normal laryngeal mucosa and cervical lymph node. Using Kruskal-Wallis H test, chi2 test, Spearman rank correlation analysis and so on to do statistical analysis.@*RESULT@#The positive expression rate of SDF-1 and CXCR4 in laryngocarcinoma was obviously higher than in paraneoplastic tissues and normal laryngeal mucosa tissues (P < 0.01). And the expression of two proteins was correlated with lymph node metastasis (P < 0.01), clinical stage (P < 0.01) and pathological grading of tumor (P < 0.05). The positive expression rate of SDF-1 and CXCR4 protein in metastasis lymph node tissue was higher than that in non metastasis lymph node tissue (P < 0.01). The expression of SDF-1 is correlated positively with the expression of CXCR4 in laryngocarcinoma.@*CONCLUSION@#SDF-1 and CXCR4 protein are highly expressed in laryngocarcinoma and in metastasis lymph node tissue. And they are correlated with lymph node metastasis, clinical stage and pathological grading of the tumor. According to the results, the two proteins may relate to infiltration and metastasis of laryngeal squamous cell carcinoma and play a role of synergistic action in the development and invasion of carcinoma of larynx.
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Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Squamous Cell , Metabolism , Pathology , Chemokine CXCL12 , Metabolism , Laryngeal Neoplasms , Metabolism , Pathology , Lymph Nodes , Metabolism , Pathology , Lymphatic Metastasis , Receptors, CXCR4 , MetabolismABSTRACT
A questionnaire survey was conducted in 724 students from three junior high schools in Shanghai Jinshan district.Total 642 students completed the questionnaire with a response rate of 88.7％,among them 75 were overweighted or obese.The positive rate of 6 out 8 unhealthy psycho-behavioral practices related to weight control in overweight or obese students was significantly higher than that of students with normal weight (all P ＜ 0.05).Binary logistic backward stepwise regression analysis showed that overweight or obesity was risk factor for the unhealthy psycho-behavior practices related to weight control in adolescent students.
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Objective To study the quantitative expression and the correlation of the NF-κB p65,COX-2 and MMP-9 Drotein in the hypopharyngeal carcinoma tissue.Methods FCM method was performed to detect the quantitative expression of the NF-κB p65,COX-2 and MMP-9 protein in 48 cases of hypopharyngeal carcinoma fresh sample and 48 cases of para-carcinoma tissue.Fluorescence Index wasdeftned as the quantitative expression index of the three proteins.Results The quantitative expression of the NF-κB p65,COX-2 and MMP-9 in hypopharyngeal carcinoma tissues(1.16,1.32 and 1.26) was remarkably higher than in para-carcinoma(1.03,1.04 and 1.04).The quantitative expression of three proteins in metastasis group was obviously higher than in non-metastasis group.The expression of NF-κB p65 and COX-2 protein in hypopharvngeal carcinoma tissues was positively related (P＜0.05). Conclusion The high expression of NF-κB p65 and COX-2 is closely related in hypopharyngeal carcinoma tissues.NF-κB p65 might improve the expression of COX-2.
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<p><b>OBJECTIVE</b>To study the contribution of puberty maturation to smoking behavior in Chinese adolescents.</p><p><b>METHODS</b>A cross-sectional survey was carried out. One thousand four hundred and fifty-three senior middle school students aged from 15 - 18 years were recruited in Shanghai in 2000. A standardized self-administrated questionnaire was designed to obtain information on smoking, age at first nocturnal ejaculation in boys, age at menarche in girls and variables that might be associated with smoking in adolescents.</p><p><b>RESULTS</b>In boys, the prevalence of experimental smoking was highest among later maturers (28.6%), followed by the earlier (21.3%) and the average (21.7%), and the prevalence of current smoking was highest among earlier maturers (16.4%), followed by the later (7.1%) and then the average (4.8%). In girls, the prevalence of ever smoked among earlier, average and later maturers were as follows: 24.2%, 12.0%, 6.3% respectively. When psychosocial variables which might be associated with smoking were under control, early maturation was a significant risk factor for current smoking in boys (OR = 3.68, 95% CI: 1.23 - 10.99), and might be a risk factor for ever smoked in girls (OR = 2.23, 95% CI: 0.89 - 5.60). Whereas late maturation might have been a risk factor for boys to experiment smoking (OR = 1.48, 95% CI: 0.72 - 3.06), while in girls it might be protective (OR = 0.64, 95% CI: 0.22 - 1.86).</p><p><b>CONCLUSION</b>Earlier or later matured boys and earlier matured girls were at higher risk of smoking. Pubertal changes and timing need to be considered in smoking prevention.</p>